Initially, 18 clinically relevant potential variables were selected from the database considering both clinical and statistical aspects from the literature review: ECOG performance status, BMI, lymph node status, portal vein thrombosis, maximum tumor diameter, number of extrahepatic metastases, presence of lung metastasis, AST level, TBIL level, albumin level, platelet count, AFP level, HBV-related cirrhosis, HCV-related cirrhosis, alcoholic cirrhosis, prior surgical resection, line of FOLFOX4 treatment, and prior sorafenib treatment. This evidence concerns the gene ALB and neoplasm.