Mice harbouring Phf6 deletion, or BFLS patient mutations exhibit altered NSC self-renewal and deregulated EphR expression, raising the question of whether knockdown of either EphA4/7 or EphB1 can phenocopy the PHF6 mutant induced eNSC phenotype in BFLS. This evidence concerns the gene EPHA4 and Borjeson-Forssman-Lehmann syndrome.