ACSS2 and neoplasm: Similarly, ACSS2 knockdown in tumour cells abrogated the stellate cell-induced increase in tumour burden (Fig. 3i,j and Extended Data Fig. 5f–h) and tumour cell proliferation rates (Fig. 3k,l and Extended Data Fig. 5i,j), without impacting apoptosis (Extended Data Fig. 5k), in athymic (AT) nude mice orthotopically co-implanted with S2-013/CFPAC-1 tumour cells and HPS cells.