We also observed increased levels of acetate in the tumour-derived interstitial fluid of the KrasLSL.G12D/+; p53R172H/+; Pdx1-Cretg/+ (KPC) mouse model of PDAC, which demonstrates a substantial amount of desmoplasia29 as compared to the pancreas from age-matched littermate controls (Extended Data Fig. 1f). The gene discussed is PDX1; the disease is neoplasm.