We demonstrated that SOCS5 displayed a positively regulatory effect on the proteins related to de novo lipogenesis (SREBP1, mSREBP1, FASN, ACC, SCD, ACLY) in three HCC cell lines (Fig. 2d, e, h), but it did not affect plasma membrane transporters of fatty acids (CD3616, FATP417; Supplementary Fig. 6d). Here, ACLY is linked to hepatocellular carcinoma.