In Gao’s HBV-related cirrhosis HCC cohort, the High SOCS5 group had a higher score of FA Biosynthesis than the Low SOCS5 group (p < 0.05; Supplementary Fig. 4e), and the expression of SOCS5 in the High-lipid group was upregulated compared to the Low-lipid group (p < 0.05; Supplementary Fig. 4f). Here, SOCS5 is linked to hepatocellular carcinoma.