In our HBV-related cirrhosis HCC cohort, Gao’s HBV-related cirrhosis HCC cohort, and TCGA HCC cohort, patients in the SOCS5( + )RBMX( + ) HCC group consistently showed the shortest OS relative to SOCS5( + )RBMX(-) group, SOCS5(-)RBMX(+) group, and SOCS5(-)RBMX(-) group, especially relative to the SOCS5(-)RBMX(-) group (P <0.05; Fig. 3l–n). Here, SOCS5 is linked to Cirrhosis.