CD40LG and Splenomegaly: The disease mainly manifested as marked splenomegaly (Fig. 1B, C), increased levels of anti-double-stranded DNA (dsDNA) antibody (Fig. 1D), severe infiltration of lymphoid cells and diffuse expansion of the mesangial matrix in kidneys (Fig. 1E), and increased glomerular deposition of IgG and IgM antibodies (Fig. 1F).