Coronary artery disease (CAD) was the most frequently genetically linked disease with a total of eight distinct protein targets that also changed during fasting (Fig. 7A-C), including four not related to lipid metabolism such as a reduction in leiomodin 1 (LMOD1) that has been previously suggested to be involved in smooth muscle cell differentiation46. The gene discussed is LMOD1; the disease is coronary artery disorder.