Exploiting our resource Polympact24 we found that 523 of the 678 functional SNPs we identified (77%) cause a putative absolute relative change >0.5 in the scores of 594 transcription factor binding motifs, of which 19 are oncogenes (including MYC, JUN, and CTNNB1), ten are tumor suppressor genes (including, TP53, PTEN, BRCA1, and CEBPA) and more generally 90 (15%) are genes implicated in cancer (Fig. 1c, Supplementary Fig. 1c and Supplementary Data 2). The gene discussed is CTNNB1; the disease is cancer.