The gene E2A has been linked to stemness, metastasis, and therapeutic resistance in breast cancer [35], however, there are no reports on its ability to distinguish between basal-like and mesenchymal types or its interaction with GRHL2. Therefore, it is important to explore the upstream regulators of FOXA1 and GRHL2 in future studies to gain a deeper understanding of their regulatory network in breast cancer. The gene discussed is FOXA1; the disease is breast cancer.