Notably, the combination of anti-PD-1 and anti-IL-10 induced significantly more tumor cell apoptosis than IgG control (p = 0.03), while the difference between either of the individual treatment groups compared to IgG control (p = 0.30 for anti-PD-1 and p = 0.09 for anti-IL-10) did not reach statistical significance (Fig. 5B). Here, IL10 is linked to neoplasm.