A recent study published September 2023 reported low (AChE) activity increases the local ACh concentrations, causing tumoral growth, aggressiveness, and metastasis observed in different cancer types and tumoral stages, and as tumors develop (AChE) content decreases more due to the overactivation of the PI3k/Akt survival pathway and overexpression of DNMT138. Here, ACHE is linked to cancer.