In order to delve deeper into the role played by C3G in enhancing insulin signaling conducting, we noted that the role of PTP1B in negatively regulating insulin receptor kinase at the molecular level has established by Myers et al. [28], and Mice with the PTP1B gene removed exhibit characteristics that imply targeting PTP1B inhibition might be a promising strategy for treating diabetes [29]. This evidence concerns the gene PTPN1 and diabetes mellitus.