BCL2 and neoplasm: BCL2 and BCL2A1 levels were also higher in BRAFV600E compared to BRAFWT tumours (Fig. 2C, D, blue), although the overall level of expression was considerably lower than that of MCL1 and BCL2L1. Collectively these findings reveal that BCL-XL and MCL-1 are the most highly expressed pro-survival factors expressed in BRAF-mutant CRCs, and that MCL-1 is further upregulated in BRAFV600E tumours.