Mice treated with TIGIT.SynNotch.aCD73 iNK cells had higher numbers of tumor-infiltrating NKp46+ and GzB+ NK cells, demonstrating not only a higher infiltration of engineered NK cells into GBM brains, but a higher functional activation compared to WT iNK cells (Fig. 6A–D). This evidence concerns the gene NCR1 and glioblastoma.