We analyzed GEO datasets GSE13355 from Nair’s study [22], GSE14905 from Yao’s study [23], and GSE30999 from Suárez-Fariñas’s study [24], we observed elevated GSDME mRNA levels in skin biopsy samples from lesional skin of moderate to severe psoriasis (PP) compared to both normal skin from healthy controls (NN) and non-lesional skin of the patients (PN) [22, 23], or just non-lesional skin of the patients (PN) [24] (Fig. 1D). This evidence concerns the gene GSDME and psoriasis.