Furthermore, both necroptosis and ferroptosis in keratinocytes have been implicated in psoriasis and IMQ-induced psoriasis-like dermatitis, through the release of inflammatory cytokines such as S100A8, S100A9, HMGB1, IL-33, IL-1β, and IL-6 [17, 18]. This evidence concerns the gene HMGB1 and psoriasis.