IFNA1 and autoimmune disease: However, previous studies have also demonstrated increased B cell activity with IL-1065, potential therapeutic benefits of IL-10 inhibition in SLE66,67; pro-inflammatory effects of IL-10 in an IFN-dominated milieu68; and role of IL-10 as autocrine factor in supporting B cell differentiation into ASC69, suggesting a complex role for IL-10 in autoimmune diseases.