OTUD4 and central nervous system cancer: To explore the expression of OTUD4 in glioblastoma, we analyzed the TCGA, CGGA, and GlioVis databases and found that compared with matched adjacent normal tissues, the expression level of OTUD4 in glioblastoma tissues was higher (Fig. 1A), and OTUD4 expression increased with glioma clinical grade deepened (Fig. 1B).