IGF2BP3 and central nervous system cancer: Consistently, human microglia (HM) cells co-cultured with IGF2BP3-KD U87 and HS683 cells also exhibited elevated p-STING levels compared to those co-cultured with control U87 and HS683 cells (Fig. 6E), indicating the potential triggering of STING activation in both glioma cells and microglia upon IGF2BP3 knockdown.