TP53 and cancer: To assess this, we re-expressed GFP-tagged caspase-2-C320G (Casp2C320G), caspase-2-D135A (Casp2D135A) or caspase-2-D330A (Casp2D330A) mutants in CASP2−/− mut- p53 cancer cells (Fig. 4a, b, d).