RUVBL1 and cancer: This included Hsp70 chaperones (HSPA8, HSPA6) and a suite of Hsp70/Hsp90 co-chaperones (DNAJB1, BAG3, DANJB6, SUGT1, NUDC and RUVBL1), suggesting that caspase-2 might protect mut-p53 cancer cells from ferroptosis through interaction with chaperone machinery.