CD8A and neoplasm: The increased activation and proliferation in the TdLN (as measured by increased Ki67+ CD8+ T cells, increased CD25+ CD8+ T cells, and a shift to an effector/effector memory phenotype in the CD8+ T cell population) was preserved with the addition of FTY720, confirming that FTY720 prevented trafficking of these newly primed T cells to the tumor (Fig. 6g, Fig. S9A).