There were largely no differences in the balance between stem-like (TCF1+ TIM-3+) vs. terminally differentiated (TCF1- TIM3+) cells in the CD8+ PD-1+ T cell compartment among the various treatment groups, although we observed a trend towards less terminally differentiated cells in the tumor in the Tx + ɑCD4 group (Fig. S5). This evidence concerns the gene TCF7 and neoplasm.