It has been depicted in multiple studies that deficiency of ALOXE3 can promote cancer cell survival and render certain cancer cells resistant to ferroptosis, including colorectal cancer (CRC), Hepatocellular carcinoma (HCC), and GBM cells [18, 37–39], and in the follow-up project, we will delve into a more detailed exploration of ALOXE3. The gene discussed is ALOXE3; the disease is hepatocellular carcinoma.