The rs1802459 variant has been suggested to play a pathogenic role in familial ALS.[20] Our patient also expressed polymorphisms in G2E2, MOBP, HLA-DOB1, SLC9A8, and COG3 as reported by Rheenen et al[21] as genome-wide significant loci. The gene discussed is SLC9A8; the disease is amyotrophic lateral sclerosis.