A multivariate analysis of the findings in this study highlights that in HNSCC, TIM-3 expression levels are strongly associated with tumor size, lymph node metastasis and TNM stage, but they are not related with gender, age, tumor location, tumor differentiation, or history of smoking or alcohol consumption.[80] Also, in patients with stage III and IV head and neck squamous cell carcinoma, overall survival (OS) and disease-free survival times are shorter in patients with high TIM-3+TIL infiltration than in those with low TIM-3+TIL infiltration. This evidence concerns the gene HAVCR2 and head and neck squamous cell carcinoma.