Both M1 and M2 macrophages have high plasticity and they can be interconverted in response to changes in the TME or therapeutic intervention, with the proportion of each form determined by the type and concentration of different signals in the tumor environment.[31–33] M1 macrophages, also known as classically activated type, exert anti-tumor effects mainly by secreting a great many factors such as carbon monoxide, TNF-α, and 1L-1. This evidence concerns the gene TNF and neoplasm.