CSF1 and neoplasm: Immunotherapy strategies for TAMs are mainly to directly reduce the number of TAMs cells and change their biological function, namely, to induce the redifferentiation of Tams and weaken their function of promoting tumor progression.[35,89,90] It was found that cancer cells further enhance the metastatic and invasive ability of cancer cells by secreting colony-stimulating factor-1 (CSF-1) to recruit and aggregate TAMs in the blood.