And blocking COX-2 or MDSCs can effectively inhibit the invasion and metastasis of NPC.[43] A studies was verified and demonstrated that lMP1-mediated glycolysis can regulate the production of IL-1β, IL-6 and GM-CSF in NPC through NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome, COX-2 and phosphorylated P-65 protein (P-p65) signaling pathways in mice, thereby promoting MDSC amplification and further inducing tumor immunosuppression in NPC.[44]. The gene discussed is CSF2; the disease is nasopharyngeal carcinoma.