Finally, 6 independent risk factors affecting SLNM were screened out from the multivariate Logistic regression analysis, including tumor location (upper inner quadrant, lower inner quadrant, upper outer quadrant, Outer and lower quadrant), number of regional lymph nodes examined (2-5), ER positive, PR positive, tumor size (T2-3), and histological grade (Grade II-III) are independent risk factors for SLNM in patients. Here, ESR1 is linked to neoplasm.