ESR1 and neoplasm: The 8 independent factors were identified (P ≤ .05): Age: Age 60 to 79 years, Age ≥ 80 years; Race: Black, American Indian/Alaska Native (AI), Asian or Pacific Islander (API); Histological grading: Grade II, Grade III; No radiotherapy; Tumor size: T2, T3; ER positive: sentinel lymph node positive, married (Table 4).