Activation of the TGF-β signaling pathway triggers collagen accumulation and is important for wound repair, but overexpression of TGF-β results in enhanced extracellular matrix and progressive fibrosis, thus winning the title of “the master regulator of fibrosis.”[5] TGF-β1 is one of the most widely studied isoforms, and is elevated in plasma, serum, and muscle tissue of patients with different skeletal myopathies. The gene discussed is TGFB1; the disease is skeletal muscle disorder.