CDC6 and cancer: Therefore, targeting Cdc6 is a potential therapeutic target for overcoming radioresistance.[34] Deng et al[12] demonstrated that NCTD can mediate the degradation of Cdc6 protein via a ubiquitin-proteasome pathway dependent on Cullin subunit 1 neddylation, subsequently inducing cancer cell apoptosis and overcoming cancer radioresistance in radiation-adaptive CNE2 and A549 cells (Table 1).