There is an increasing number of studies on the correlation between VDR polymorphisms and the risk of BPH, but the results remained inconclusive.[23,24] VDR may be may be a potential target gene for the treatment of BPH.[25,26] BPH was considered a hereditary disease, and the difference in VDR genotypes had a significant influence on the occurrence of BPH.[20] A meta-analysis with 7 literature was implemented in 2014, which seemed to be out of date because of new appeared analysis.[9] The shortage of this study was that they only carried out the overall analysis besides Taq-1 polymorphism. The gene discussed is VDR; the disease is benign prostatic hyperplasia.