HT is considered to be the most common autoimmune disease.[27] It is considered a typical, organ-specific, autoimmune disease, characterized by autoimmune-mediated destruction of the thyroid gland.[28] Patients with Hashimoto thyroiditis and overt hypothyroidism are generally treated with lifelong thyroid hormone therapy.[29] The drug can significantly improve the patient thyroid function, but long-term use may induce cardiovascular system, bone metabolism and other related complications. The gene discussed is TG; the disease is autoimmune disease.