In a previous study, CRP, ESR, and SII were found to be successful in monitoring response to treatment in patients with RA and the predictive value of SII was found to be the highest compared to CRP, and ESR.[28] Compared to the previous study, the sensitivity and specificity of SII were found to be lower than in our study.[28] They performed statistical analysis only in the patients with RA on anti-TNF treatment. This evidence concerns the gene TNF and rheumatoid arthritis.