AKT1 and colorectal carcinoma: Furthermore, it has been reported that NETO2 is aberrantly expressed in various cancers, and its knockdown in human colorectal carcinoma cell line led to changes in the expression of transcripts involved in the circadian rhythm and various major signaling pathways, including Wnt, transforming growth factor (TGF)-β, Janus kinase (JAK)-signal transducer and activator of transcription (STAT), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathways [47].