As a result, the inactivation of the enzymes involved in MUFA-PL synthesis, such as stearoyl-CoA desaturase 1 (SCD1) and acyl-CoA synthetase long-chain family member 3 (ACSL3), sensitizes cancer cells to ferroptosis (Luis et al., 2021; Magtanong et al., 2019). The gene discussed is ACSL3; the disease is cancer.