KEAP1 and cancer: (Of note, additional studies have revealed a ferroptosis suppressive function of p53 under certain conditions (Tarangelo et al., 2018; Xie et al., 2017), suggesting a context-dependent role of p53 in ferroptosis regulation (Liu and Gu, 2022) Other tumor suppressors, such as BAP1, fumarase, and kelch-like ECH-associated protein 1 (KEAP1), have similarly been demonstrated to promote ferroptosis in cancer cells (Gao et al., 2019; Koppula et al., 2022; Sun et al., 2016; Zhang et al., 2018).