BRAF and metastatic malignant neoplasm in the lymph nodes: Lymph-node metastasis at diagnosis in ~25%. Lung as only site of metastasis more frequent than in follicular carcinoma. Bone metastasis less frequent than in follicular carcinoma. Overall, better prognosis than follicular carcinoma. BRAF V600E mutation associated with more aggressive disease and RAI refractoriness.