Recently, our research group demonstrated that taiep rats have a point mutation in Tubb4a gen and its corresponding protein TUBB4A (OMIM 602662), with pathological characteristics similar to the human leukodystrophy hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC); [7, 8]. The gene discussed is TUBB4A; the disease is leukodystrophy.