,75,76 Thus, we demonstrate across dozens of cancer types, thousands of patients, and hundreds of thousands of tumor-infiltrating CD8+ T cells that NKG2A+ biases associate with increased survival and immune infiltration of tumors, as confirmed through in situ measurements, possibly due to the acquirement of a TRM phenotype by NKG2A+ CD8+ T cells that allows for sustained anti-tumor effector T cell responses. Here, CD8A is linked to cancer.