However, disruption of the integrity of the intestinal lining integrity is not completely corrected with ART (Zicari et al., 2019), and therefore malabsorption leading to increased lactose, TKT deficiency resulting in increased polyols, and 3-methylcrotonyl-CoA carboxylase deficiency resulting in elevated 3-hydroxyisovaleric acid might not be entirely corrected with ART. This evidence concerns the gene TKT and hyperinsulinemic hypoglycemia, familial, 4.