A comparative analysis of differential proteomic data revealed 7 hypermethylated or down-regulated genes (e.g., FBN1, LPP, SOD3) and 61 hypomethylated or up-regulated genes (e.g., HBE1, SNRPF, TPD52), which contributed to the early diagnosis of gallbladder cancer [18]. The gene discussed is TPD52; the disease is gallbladder cancer.