Compared with adenomas, Galamb et al. found that the methylation levels of AXIN2, DKK1, VANGL1, and WNT5A gene promoters in colorectal cancer were higher, while the methylation levels of SOX17, PRICKLE1, DAAM2 and MYC were lower, and subsequently confirmed the negative correlation between expression and methylation [19]. The gene discussed is VANGL1; the disease is adenoma.