Increasing evidence has demonstrated that blocking some key enzymes in the fatty acid synthesis pathway can reduce the uptake of lipids by tumours, thereby exerting anti‐tumour effects, such as ATP citrate lyase (ACLY), Acetyl‐CoA synthetase (ACS), Acetyl‐CoA carboxylase 1 (ACC1), Fatty acid synthase (FASN), Sterol regulatory element binding transcription factor 1 (SREBF1), etc.16, 17, 18, 19ACLY catalyses the Mg‐ATP‐dependent conversion of citrate and CoA to acetyl‐CoA and oxaloacetate.20, 21. The gene discussed is ACLY; the disease is neoplasm.