IFNLR1 and neoplasm: While we found greater accumulation of neutrophils in skin lesions from Ifnlr1−/− mice compared to wild-type mice and showed that neutrophils were necessary for the severe skin pathology observed in Ifnlr1−/− mice, the mechanism by which IFN-λ modulates neutrophil function to protect against HSV-1 skin disease remains unclear.