A majority (5119) of these genes showed increased gene expression in CDX and PDX tumours compared to cells, with similar expression between CDX and PDX tumours (Fig. 1E; orange), while a much smaller number of genes (975) showed decreased expression in CDX and PDX tumours compared to cells, and similar CDX/PDX expression (Fig. 1E; light blue). The gene discussed is PODXL; the disease is neoplasm.