CD8A and neoplasm: Brennick and George et al. (62), who performed the unbiased analysis of all 279 mutation-generated candidate neoepitopes for their ability to mediate tumor control, observed, remarkably, that none of the nine neoepitopes that mediated tumor control elicited a measurable CD8+ T cell response in vitro, even though the tumor control mediated by them was CD8 dependent, as shown by in vivo depletion.