The decrease in arthritis severity in addition to macrophage infiltration was similarly reproduced in myeloid-specific Nfat5-deficient mice (LysM-Cre;Nfat5fl/fl mice) (Figure 5, E and F and Supplemental Figure 4D), demonstrating a specific proarthritic effect of myeloid NFAT5 under high SAA concentrations. This evidence concerns the gene NFAT5 and Arthritis.