In our study, reduced interaction between myeloid‐derived TGFB1 and TGFBR1 in tumour foci No. 2 contributed to tumourigenesis and increased heterogeneity, which was support by the spatial‐geneset‐score and nichenet analysis, quantitate PCR and cell proliferation validation results. This evidence concerns the gene TGFBR1 and neoplasm.