Accompanying these were decreases in the mRNA expression of microglial activation, disease‐associated microglia (DAM), and AD‐related genes such as Cst7, Axl, Trem2, Clu, and Abca7 in several 5x‐CC lines (5x‐CC002, 5x‐CC006, 5x‐CC013, 5x‐CC017) compared to 5x‐B6J (Figure 3I‐J, Figure S3F‐H). This evidence concerns the gene ABCA7 and Alzheimer disease.