Accompanying these were decreases in the mRNA expression of microglial activation, disease‐associated microglia (DAM), and AD‐related genes such as Cst7, Axl, Trem2, Clu, and Abca7 in several 5x‐CC lines (5x‐CC002, 5x‐CC006, 5x‐CC013, 5x‐CC017) compared to 5x‐B6J (Figure 3I‐J, Figure S3F‐H). Here, TREM2 is linked to Alzheimer disease.