CLCs, a hallmark of eosinophilic inflammation, have been reported in several Th2 inflammatory disorders, including asthma, CRS, and other eosinophil-associated diseases [17] CLCs have been shown to induce the release of the proinflammatory cytokine IL-1β, which plays a role in eosinophilic immune functions [18]. Here, IL1B is linked to congenital rubella syndrome.