On the other hand, ANGPTL2 has been proposed to promote physiological remodeling and maintenance of tissue homeostasis (Kadomatsu et al., 2014; Thorin-Trescases et al., 2021); for example, administration of resident cardiac cells expressing ANGPTL2 in rats after myocardial infarction improved LV function and increased neovascularization (Li et al., 2017). Here, ANGPTL2 is linked to myocardial infarction.