Alterations in SERPINB5 expression have been observed in UC epithelial cells (Planell et al., 2013), while TRIM29 has been demonstrated in promoting pyroptosis of diabetic nephropathy podiocytes through the NF-kB/NLRP3 inflammasome pathway (Xu et al., 2023). The gene discussed is SERPINB5; the disease is diabetic kidney disease.