Interestingly, the genes interacting with variant lncRNAs were mainly associated with signaling pathways (ErbB, Ras, PI3K/AKT, p53, FoxO) and infections (for example, HIV-1, HSV, CMV, and hepatitis C), suggesting their role in the immune response during infection (Figure 4D, Supplementary Table S5F). This evidence concerns the gene TP53 and infection.