CD47 and neuroblastoma: For instance, CD47 monoclonal antibody induced similar levels of apoptosis in JinB8 cells, which express human CD47 isoforms 1 and 2 equally (55); forced expression of mouse CD47 isoform 2 or 4 in N1E-115 neuroblastoma cells induced marked neurite and filopodium formation (10); all four isoforms interacted with αv integrin to equal degrees to mediate vitronectin(Vn)-bead binding (56); and isoforms 1 and 2 activated T cells in both humans and mice to equal degrees (12, 57).