PPARGC1A and nosocomial infection: Although our data revealed that PGC1α expression in NK cells is not associated with the risk of nosocomial infection in CCI, the activity of NRF1 is regulated by PGC1α, and NRF1 regulates the nuclear genomic transcription of genes related to respiratory complexes, mitochondrial protein transport, mitochondrial genomic transcription, and protein translation (38).