In lung adenocarcinoma, tumor-associated macrophages induced the expression of VEGFC and VEGFR3 in tumor cells inducing lymphangiogenesis and metastasis, and VEGFR3 inhibition enhanced lung adenocarcinoma cell chemosensitivity through upregulation of proteins p53 and PTEN (173). The gene discussed is FLT4; the disease is lung adenocarcinoma.