Specifically, tumors secrete cytokines such as VEGF, endothelin 1, EGF-like domain-containing protein 7 (EGFL7), and fibroblast growth factor 2 (FGF2) which induce downregulation of endothelial expression of selectins, adhesion molecules, chemokines to inhibit leukocytes migration and generate a tumor immune-privileged microenvironment (10). This evidence concerns the gene VEGFA and neoplasm.