LGALS8 and neoplasm: Gal-1, Gal-3, and Gal-8 have been demonstrated to engage integrins or other cell surface proteins to mediate adhesion of tumor cells to extracellular matrix proteins and homotypic cell adhesion, or to inhibit adhesion favoring tumor cell detachment, dissemination through blood or lymph vessels and the attachment to ECs or basement membrane proteins at distal sites.