This metastatic process is also supported by tumor microenvironment deriving pro-inflammatory cytokines (IL-3, IL-6, and IL-8) and growth factors (bFGF, G/GM-CSF, IGF1, PDGF, and TGF-β), as well as other factors like Notch, calcineurin, biglycan, Jag1, and Slit2 (204). This evidence concerns the gene FGF2 and neoplasm.