Another study showed that targeting bicarbonate transporters (e.g. SLC4A4) known to contribute to extracellular pH during progression of pancreatic adenocarcinomas (PDAC) (28) reduces tumor acidity, increases activation, cytotoxic activity, and perfusion of CD8+ T-cells, and sensitizes PDAC-bearing mice to immune checkpoint inhibition (28). Here, CD8A is linked to neoplasm.